Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome

Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome

Blog Article

Atypical haemolytic uraemic syndrome (aHUS) is a form of thrombotic microangiopathy precipitated by unopposed complement activation, the treatment of which has been revolutionised by the availability of the monoclonal anti-complement (C5) antibody, eculizumab.Historically, women with aHUS would be unable to achieve a successful pregnancy due to the severity sten jacket m of their renal disease and for the few who could conceive, recurrence of aHUS was a significant risk.In spite of this, parenthood remains a priority for many.Experience with eculizumab use in the management of aHUS during pregnancy is growing and with it comes a significant change in the course of the disease.We present the case of a 28-year-old woman diagnosed with severe aHUS in the first trimester of her first pregnancy.

She received rescue therapy with eculizumab and had a return to normal renal function.While this pregnancy was lost, she strongly desired a family.We managed her through a subsequent opi the color that keeps on giving pregnancy while receiving eculizumab.This pregnancy was uncomplicated and carried to term and she birthed a healthy 2500 g baby girl.The complexities of managing a pregnancy in a woman with a history of aHUS are vast but not insurmountable, as demonstrated by this case.